Sedation with non sedating antihistamines

20-Jun-2017 06:32

Drugs subject to high first-pass metabolism may have higher oral availability in premature or term infants due to impaired ability to metabolise on first-pass.Adult metabolic capacity is attained towards the latter part of the infant's first year of life.Generally, adult glomerular filtration rates (adjusted for the difference in surface area) are attained by five to six months of age.

Generally, drugs that are poorly absorbed or have high first-pass metabolism are less likely to be problematical during breastfeeding.Many mothers are required to use drugs during breastfeeding.Almost all drugs transfer into breast milk and this may carry a risk to a breastfed infant.Feeding immediately prior to a dose may help to minimise infant exposure as concentrations in milk are likely to be lowest towards the end of a dosing interval.

However, for some drugs, milk concentrations lag behind plasma concentrations.As a general rule, maternal use of topical preparations such as creams, nasal sprays or inhalers would be expected to carry less risk to a breastfed infant than systemically administered drugs.